Jacob Witten, PhD
Assistant Professor, Department of Genetics & Genome Sciences
Jacob's research focuses on integrating AI with novel high-throughput screening approaches to design lipid nanoparticles for gene therapy. He received his PhD in Computational and Systems Biology from MIT and was a postdoctoral fellow with Dr. Daniel Anderson.
Peng Ning, PhD
Postdoctoral Researcher
Peng is developing lipid nanoparticles for RNA delivery.
Shashi Singh, PhD
Postdoctoral Researcher
Shashi's research develops scalable platforms for targeted RNA delivery and gene editing by combining nanoparticle engineering with high-throughput screening. He uses self-amplifying RNA and ADAR-mediated editing to achieve efficient, low-dose gene modulation in hard-to-target tissues and explores DNA-encoded library–based multiplexed screening to discover new ASO delivery platforms for modulating RNA splicing. He earned his PhD in RNA Biology and Post-Transcriptional Gene Regulation from Jawaharlal Nehru University (New Delhi, India) and was a postdoctoral fellow with Dr. Joseph Luna at Case Western Reserve University (2022–2026) and at Cleveland Clinic (2019–2022).
Hong Wang
PhD Student, Department of Biomedical Engineering
Hong's research develops high-throughput screening platforms for targeted systemic drug delivery by combining nanoparticle engineering with multiplexed ex vivo and in vivo biological assays. He is a graduate researcher at Case Western Reserve University, where he established foundational expertise in long non-coding RNAs (lncRNAs) and immune responses in cancer through collaborative research with Dr. William P. Schiemann.
Additional positions available — see the Join page.
Contact Dr. Witten if interested in research opportunities.