Witten Lab

Welcome Shashi Singh to the Lab

Wed, 01 Apr 2026 00:00:00 +0000

We are excited to welcome Dr. Shashi Singh to the Witten Lab as a postdoctoral researcher. Shashi’s research will develop scalable platforms for targeted RNA delivery and gene editing by combining nanoparticle engineering with high-throughput screening. He earned his PhD from Jawaharlal Nehru University and was previously a postdoctoral fellow with Dr. Joseph Luna at Case Western Reserve University and Cleveland Clinic.

Welcome Peng Ning to the Lab

Fri, 13 Feb 2026 00:00:00 +0000

We are excited to welcome Dr. Peng Ning to the Witten Lab as a postdoctoral researcher. Peng will be joining us in 2026 and will be developing lipid nanoparticles for RNA delivery.

Lab Opening at Case Western Reserve University

Sun, 01 Feb 2026 00:00:00 +0000

The Witten Lab officially opens at Case Western Reserve University in the Department of Genetics & Genome Sciences. We are excited to begin building our research program at the intersection of artificial intelligence and gene therapy.

Our lab focuses on developing AI-driven approaches to design lipid nanoparticles for treating lung diseases. We combine computational methods with experimental validation to accelerate the development of next-generation gene therapies.

We are actively recruiting graduate students and postdocs to join our team. If you’re interested in working at the intersection of machine learning and bioengineering, please visit our page for more information.

Wed, 01 Jan 2025 00:00:00 +0000

Biotechnology in Materials Science: A Storied Past and a Bold Future

Wed, 01 Jan 2025 00:00:00 +0000

Lipid Nanoparticle Database towards structure-function modeling and data-driven design for nucleic acid delivery

Wed, 01 Jan 2025 00:00:00 +0000

NumSimEX: A Method Using EXX Hydrogen Exchange Mass Spectrometry to Map the Energetics of Protein Folding Landscapes

Wed, 01 Jan 2025 00:00:00 +0000

Artificial intelligence-guided design of lipid nanoparticles for pulmonary gene therapy

Sun, 01 Dec 2024 00:00:00 +0000

Recent advances in nanoparticulate RNA delivery systems

Fri, 01 Mar 2024 00:00:00 +0000

Inhalable Dry Powders for Lung mRNA Delivery

Mon, 01 Jan 2024 00:00:00 +0000

Zwitterionic Polymer-Functionalized Lipid Nanoparticles for the Nebulized Delivery of mRNA

Mon, 01 Jan 2024 00:00:00 +0000

A comparison of the physicochemical properties of native mucus and reconstituted mucin gels

Wed, 01 Feb 2023 00:00:00 +0000

Combinatorial development of nebulized mRNA delivery formulations for the lungs

Sun, 01 Jan 2023 00:00:00 +0000

Enhancing the immunogenicity of lipid-nanoparticle mRNA vaccines by adjuvanting the ionizable lipid and the mRNA

Sun, 01 Jan 2023 00:00:00 +0000

Spatial configuration of charge and hydrophobicity tune particle transport through mucus

Sat, 01 Jan 2022 00:00:00 +0000

Deep learning regression model for antimicrobial peptide design

Mon, 01 Jul 2019 00:00:00 +0000

Molecular characterization of mucus binding

Mon, 01 Apr 2019 00:00:00 +0000

Computational Insights into Avidity of Polymeric Multivalent Binders

Tue, 01 Jan 2019 00:00:00 +0000

Mucus and mucin environments reduce the efficacy of polymyxin and fluoroquinolone antibiotics

Tue, 01 Jan 2019 00:00:00 +0000

Selective permeability of mucus barriers

Wed, 01 Aug 2018 00:00:00 +0000

The particle in the spider's web: transport through biological hydrogels

Thu, 01 Jun 2017 00:00:00 +0000

Charge influences substrate recognition and self-assembly of hydrophobic FG sequences

Sun, 01 Jan 2017 00:00:00 +0000

Probing the potential of mucus permeability to signify preterm birth risk

Sun, 01 Jan 2017 00:00:00 +0000

Mapping Protein Conformational Landscapes under Strongly Native Conditions with Hydrogen Exchange Mass Spectrometry

Wed, 01 Jul 2015 00:00:00 +0000

Micro-heterogeneity metrics for diffusion in soft matter

Wed, 01 Jan 2014 00:00:00 +0000

Preparation of two novel monobrominated 2-(2',4'-dihydroxybenzoyl)-3,4,5,6-tetrachlorobenzoic acids and their separation from crude synthetic mixtures using vortex counter-current chromatography

Sun, 01 Jan 2012 00:00:00 +0000

Vortex Counter-Current Chromatography: Performance of a New Preparative Column

Sun, 01 Jan 2012 00:00:00 +0000